Spence will start Friday in Kansas City, Martin Gallegos of MLB.com reports.
Advice: It will be the first major-league start for Spence, who has posted a 4.26 ERA and 22:7 K:BB over 25.1 innings covering 11 relief appearances. The Rule 5 pick will be pitching on three days' rest after allowing two runs over two-thirds of an inning on Monday in Houston. Spence has gone three-plus frames in six of his appearances, which includes a season-long 4.2-inning outing on May 5 versus the Marlins. However, this could wind up being a piggyback situation, with Kyle Muller also available to go multiple innings.
Rotowire.com
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